Drug Action at the Molecular Level

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FAQ Policy. Table of contents 14 chapters Table of contents 14 chapters Chemical constitution and prototropic equilibria in structure — activity analysis Pages Ganellin, C.

Drug action - Wikipedia

Calculation of essential drug conformations and electron distributions Pages Richards, W. The conformation of hormonal peptides in solution Pages Feeney, J. Structure and function of carbonic anhydrase: comparative studies of sulphonamide binding to human erythrocyte carbonic anhydrases B and C Pages Kannan, K. Kinetic aspects of structure — activity relationships in the carbonic anhydrase — sulphonamide system Pages King, R. The haemoglobin molecule as a model drug receptor Pages Goodford, P. Substrate and inhibitor binding to dihydrofolate reductase Pages Roberts, G.

Tetrahydrobiopterin plays an essential role in the production of aromatic amino acids, neurotransmitters and nitric oxide. PDB helps teachers, students, and the general public explore the 3D world of proteins and nucleic acids. Learning about their diverse shapes and functions helps to understand all aspects of biomedicine and agriculture, from protein synthesis to health and disease to biological energy.

Why PDB? PDB builds introductory materials to help beginners get started in the subject "", as in an entry level course as well as resources for extended learning. Toggle navigation PDB Educational portal of. You and Your Health. Immune System.

Opioids Mechanism of Action, Addiction, Dependence and Tolerance, Animation

Toxins and Poisons. Drug Action. Antimicrobial Resistance. Drugs and the Brain. Protein Synthesis. Molecular Infrastructure. Biological Energy. Molecules and the Environment. Biology of Plants.

Molecular Motors. Cellular Signaling.

Nucleic Acids. Bioluminescence and Fluorescence. Molecular Evolution. Recombinant DNA. Renewable Energy. Biomolecular Structural Biology. PDB Data. Visualizing Molecules. Nobel Prizes and PDB structures. Grid List. Adrenergic Receptors. Aminoglycoside Antibiotics. Aminoglycoside Antibiotics and Resistance. Circadian Clock Proteins. Cytochrome p Dihydrofolate Reductase. Estrogen Receptor.

Glutamate-gated Chloride Receptors. Glutathione Transferases. HIV Envelope Glycoprotein. Influenza Neuraminidase. Lactate Dehydrogenase. Multidrug Resistance Transporters. Neurotransmitter Transporters. New Delhi Metallo-Beta-Lactamase.

Dipartimento di Scienze del Farmaco

Nitric Oxide Synthase. Opioid Receptors. Penicillin-binding Proteins. Serotonin Receptor. Tetrahydrobiopterin Biosynthesis. Actinomycin Some antibiotics attack cells by intercalating between the bases in a DNA double helix Adrenergic Receptors Adrenaline stimulates a G-protein-coupled receptor, priming us for action Aminoglycoside Antibiotics Antibiotic-resistant bacteria build enzymes that destroy drugs like streptomycin Aminoglycoside Antibiotics and Resistance Bacteria become resistant to aminoglycosides by destroying them or changing their target.

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Beta-secretase Beta-secretase trims proteins in the cell and plays an important role in Alzheimer's disease Circadian Clock Proteins Circadian clock proteins measure time in our cells Cyclooxygenase Aspirin attacks an important enzyme in pain signaling and blood clotting Cytochrome p Cytochrome p detoxifies and solubilizes drugs and poisons by modifying them with oxygen Dihydrofolate Reductase DHFR is a target for cancer chemotherapy and bacterial infection Estrogen Receptor Estrogen binds to receptors in the nucleus and affects key genes in development Glutamate-gated Chloride Receptors The antibiotic ivermectin attacks glutamate-gated chloride channels, paralyzing parasitic worms.

Glutathione Transferases Glutathione transferase tags toxic molecules, making them easy to recognize and remove. Vancomycin The antibiotic vancomycin blocks the construction of bacterial cell walls. How do Drugs Work? Insulin and Diabetes.

The drug of good and evil

How Do Drugs Work? The Ribosome. Ribosomal Subunits. Penicillin and Antibiotic Resistance. PDB structures allow us to see how drugs bind to their protein targets in exquisite detail. PDB structures are used to discuss antibiotics and antivirals, chemotherapy, drug metabolism, drugs of signaling proteins, and lifestyle drugs.

Current Molecular Pharmacology

Structural biology has revealed the details of insulin signaling and how this knowledge is being used to create new and better treatments for diabetes. This flyer commemorates the Nobel Prize in Chemistry for studies of the structure and function of the ribosome. Atomic structures of the ribosomal subunits reveal a central role for RNA in protein synthesis.